mutations presented The point that, as defined underneath, CLL therapy is based around the presence or absence of these mutations. The present consensus is, aside from clonal mutations, subclonal mutations using a variant allelic frequency starting from 5 to ten% (and thus underneath the brink of detection by typical molecular strategies) is also claimed, While Those people using a variant allelic frequency reduced than 5% must not, but there is A great deal controversy all over these problems and this suggestion could adjust Sooner or later.

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